An Uncommon Blood Group Isoantibody (Anti-M) in Neoplastic Disease

THE first case in this series of anti-M sensitized patients was reported in 1958 because it presented a unique exception to the generalization that cold agglutinins are without significance in transfusion practice. The patient had received no M stimulus from either previous transfusion or pregnancy. We commented: “The possibility of a relation between the abnormal isoantibody and the patient's carcinoma of the cecum is being investigated”1.