The Effects of the Reinforcing Kidney and Activating Blood Recipe Affecting the Expression Level of Inos and PDE5 in the Tissue of Corpus Cavernosum Smooth Muscle of DMED-rats

Objective: Observing the effects of reinforcing kidney and activating blood recipe affecting the value of inos and PDE5 in the tissue of corpus cavernosum Smooth muscle of DMED-rats.Methods: An animal model of diabetes was induced by a single intravenous dose of streptozotocin(STZ,60mg·kg-1 body weight) in Wistar rats.Recording the numbers of penile erection of each rat by camera after subcutaneous inject of apomorphine(80mg·kg-1).Screening the model of STZ-rats with erectile dysfunction and grouping into 6 groups: control group,model group,Chinese Medicine group,low-dosage group,Diamicron group,Diamicron combined Testosterone Undecanoate group.After administrating 12 weeks,observed the expression level of inos and PDE5 in the tissue of corpus cavernosum smooth muscle of DMED-rats.Results: The reinforcing kidney and activating blood recipe can improve the expression level of inos and PDE5.Conclusion: The reinforcing kidney and activating blood recipe has significant protective effect of inos and PDE5 in the tissue of corpus cavernosum smooth muscle of DMED-rats.