Serum thyroid hormone levels in patients with liver disease.

Levels of serum triiodothyronine (T 3 ), reverse triiodothyronine (rT 3 ), and thyroxine (T 4 ) were determined in 29 patients with alcoholic cirrhosis, seven patients with acute hepatitis, and 14 control patients hospitalized for chronic disease. Serum T 3 levels were decreased significantly and serum rT 3 levels increased significantly in the patients with alcoholic cirrhosis. Serum T 3 and T 4 levels were lower and rT 3 levels higher in the cirrhotic patients who died within three months of the study compared with those who survived. A combination of prothrombin time, aminopyrine breath test results, and rT 3 and T 3 determinations gave significant predictive information about survival in patients with cirrhosis. The data suggest that assay of serum thyroid hormone levels together with prothrombin time and the aminopyrine breath test may be helpful in assessing the course and prognosis of patients with liver disease. ( Arch Intern Med 139:1117-1120, 1979)