Development of a physiologically based pharmacokinetic model for mefloquine and its application alongside a clinical effectiveness model to select an optimal dose for prevention of malaria in young Caucasian children

Trevor N. Johnson,Yumi Cleary,Neil Parrott,Bruno Reigner,James Smith,Stephen Toovey

Development of a physiologically based pharmacokinetic model for mefloquine and its application alongside a clinical effectiveness model to select an optimal dose for prevention of malaria in young Caucasian children

2019

Trevor N. Johnson
Yumi Cleary
Neil Parrott
Bruno Reigner
James Smith
Stephen Toovey

Aims To predict the optimal chemoprophylactic dose of mefloquine in infants of 5–10 kg using physiologically based pharmacokinetic (PBPK) and clinical effectiveness models.

Keywords:

Mefloquine
Anesthesia
Pharmacodynamics
Malaria
Pharmacology
Pharmacokinetics
Medicine
Pediatrics
Physiologically based pharmacokinetic modelling
Population
Clinical trial
Chemoprophylaxis

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