IDH 1 /2 status and low grade gliomas (LGG): Correlation with outcome upfront Pignatti criteria and molecular profile in a retrospective analysis of a single-centre cohort from Spain.

2046 Background: Current therapy of LGG is based on clinical, radiologic and histologic ( Pignatti prognostic classification ) features .In the last years genomic profile of LGG has been investigated showing a new tool to guide therapy . Methods: IDH analysis was performed by IDH1 and IDH2 genes sequencing in a series of 58 LGGs diagnosed from 1991 to 2012 and correlated with histology , Pignatti classification , molecular profile ( p53 expression , 1p19q deletion status and MGMT promoter methylation ) and outcome. Results: 56.9% of the pts were male and mean age was 45 years . Histological distribution was 39.7% , 22.4% and 37.9% for Astrocytoma (A), Oligodendroglioma (OD) and Oligoastrocytoma (OA) , respectively . Surgical resection was total in 41.4% , subtotal in 19% and only biopsy in 39.7% of the cases . Pts were classified by Pignatti criteria. Inmediate postsurgery therapy was administered performed in 41.4% of pts. IDH alterations were found in 61.9% ( 26/42) , 1p19q codeletion in 46.3% ( 25/54),...