Library assembly of mono-, di- and tri-O-sulfated β-D-xylopyranosides; effect of O-sulfation on pyranose ring conformation

With molluscan sulfatase-catalyzed de-O-sulfation reactions, a series of mono-, di- and tri-O-sulfated p-nitrophenyl β-D-xylopyranosides were assembled and applied to a 1H NMR study to examine the effect of O-sulfate groups on the equilibration between pyranose 4C1 and 1C4 conformations.