A Comparison of the Duration of Action of Various Long-Acting ACTH Preparations in Human Subjects

ONE criterion of the effectiveness of long-acting ACTH preparations is their duration of action. Using a simple technic, we have compared the duration of action of two types of aluminum phosphate adsorbed ACTH preparations (Adactar and Adactar Tannate) with that of certain nonadsorbed ACTH preparations. The residual eosinopenia persisting twenty-four hours after a single dose of 100 USP units of these ACTH preparations has been used as a semiquantitative method of comparing their duration of action. This type of assay may be used only in subjects who are not already receiving ACTH or cortisone. For subjects under such treatment, other . . .