The TetO rat as a new translational model for type 2 diabetic retinopathy by inducible insulin receptor knockdown

Aims/hypothesis Although the renin–angiotensin system plays an important role in the progression of diabetic retinopathy, its influence therein has not been systematically evaluated. Here we test the suitability of a new translational model of diabetic retinopathy, the TetO rat, for addressing the role of angiotensin-II receptor 1 (AT1) blockade in experimental diabetic retinopathy.