Adenosquamous Carcinoma of the Prostate: A Rare Subtype

The vast majority of prostate cancers are acinar adenocarcinomas. Histological variants of prostate cancer are rare. An unusual case of adenosquamous carcinoma (ASCC) in a 61 year old gentleman is described. The incidence is less than 1% of all prostatic carcinomas and usually occurs after previous radiation or hormonal therapy. This case is exceptionally rare as it occurred de novo with no previous radiation or hormonal therapy. Prostatic adenocarcinoma with squamous was diagnosed after a trans-perineal ultrasound guided biopsy of the prostate was performed due to an abnormal prostate felt on digital rectal examination. Staging investigations revealed no distant metastatic disease. A robotic assisted radical prostatectomy and pelvic lymphadenectomy was performed. The patient went on to have salvage radiotherapy and adjuvant chemotherapy. He was doing well 6 months post operatively with no radiological evidence of recurrence on PSMA PET scan.