Combined Asymmetric Aminocatalysis and Carbene Catalysis

The use of multiple catalytic systems for cascade reactions has found widespread application in recent years. The combination of two important organocatalysts, chiral amines and N-heterocyclic carbenes (NHCs), is of extraordinary interest since they can both potentially mediate a variety of reactions with aldehyde derivatives. In this short review, we discuss the successful combination of asymmetric aminocatalysis and carbene catalysis in the efficient construction of complex chiral architectures, either in a relay or sequential manner. 1 Introduction 2 NHC-Catalyzed Redox Reaction Combined with Aminocatalysis 3 NHC-Catalyzed Benzoin Condensation Combined with Aminocatalysis 4 NHC-Catalyzed Stetter reaction Combined with Aminocatalysis 5 Miscellaneous NHC Catalysis Combined with Aminocatalysis 6 Summary