SINGLE NUCLEOTIDE POLYMORPHISMS IN CHOLESTERYL ESTER TRANSFER PROTEIN (CETP) GENE ARE NOT ASSOCIATED WITH RECURRENT CARDIOVASCULAR EVENTS OR MORTALITY IN PATIENTS WITH ESTABLISHED ATHEROSCLEROSIS: A MENDELIAN RANDOMIZATION EXPERIMENT

methods: Among TexGen registry participants (n = 3717) with established atherosclerosis (those with acute coronary syndrome [ACS] or undergoing coronary artery bypass grafting [CABG]) and available prospective follow-up; we evaluated whether CETP gene variants previously associated with reduced CETP activity and HDL-cholesterol increase (rs708272, rs12149545) are associated with a reduction in recurrent myocardial infarction [MI] (primary outcome), recurrent revascularization, or death (secondary outcomes).