Cellular Content of UDP-N-acetylhexosamines Controls Hyaluronan Synthase 2 Expression and Correlates with O-Linked N-Acetylglucosamine Modification of

Hyaluronan, a high molecular mass polysaccharide on thevertebrate cell surface and extracellular matrix, is produced atthe plasma membrane by hyaluronan synthases usingUDP-GlcNAcandUDP-GlcUAassubstrates.Theavailabilityofthese UDP-sugar substrates can limit the synthesis rateof hyaluronan. In this study, we show that the cellular level ofUDP-HexNAc also controls hyaluronan synthesis by modu-lating the expression of