Prostate Cancer Treatment Based on the Suppression of Andiogenesis and Metastasis

Abstract : A polymeric form of fibronectin, superfibronectin (sFN), is a novel non-cytotoxic compound that has impressive anti-metastatic effects in animal experiments. It is thought to act by interfering with adherence and/or migration of tumor cells in the host. Metastases originating from human melanoma, sarcoma and carcinoma cells have been found to be suppressed by sFN. In this stage for the project, we proposed to determine the feasibility of using sFN as an anti- prostate cancer agent by addressing three important issues: 1) demonstration that sFN is effective in preventing the spread of established tumors; 2) lack of detailed studies regarding the toxicity of sFN; and 3) lack of standardization of the sFN polymerization process.