Small intestinal malabsorption in chronic alcoholism determined by 13C-D-xylose breath test and microscopic examination of the duodenal mucosa

AbstractObjective. Diarrhea, weight loss and osteoporosis are prominent symptoms and clinical signs of alcoholism. One of several possible factors causing this clinical picture is small intestinal damage leading to malabsorption. The aim of this study was to prospectively evaluate small intestinal absorption in alcoholics using the 13C-D-xylose breath test, and to relate the breath test results to morphological findings of the duodenal mucosa. Material and methods. Sixteen alcoholics without liver failure or serious illness and presenting symptoms of dyspepsia, nausea or diarrhea were included. The 13C-D-xylose breath test was performed in 14 of the included subjects. The breath tests of the alcoholics were compared to those of untreated coeliac patients and healthy subjects. Duodenal biopsy specimens were taken for assessment of epithelial morphology in 14 of the included subjects, using light- and electron microscopic techniques. Results. Alcoholics had significantly reduced absorption of 13C-D-xylose c...