812 Non-Hodgkin's lymphoma of intermediate degree. 13-year follow-up of 89 patients treated with chop

From January 981 to January 1993, 89 patients with non-Hodgkin's lymphoma of intermediate degree were treated with 6 courses of CHOP chemotherapy. The median age of these patients was 57 years and male/female ratio was 1.53. 8 of the patients were large-cell follicular lymphomas, 33 diffuse small-cell, 25 diffuse mixed and 22 diffuse large cell. The lymphatic areas most affected were: para-aortic 16%, left cervical 14%, right cervical 13% and mesenteric 11%. The number of lymphatic areas affected were: 1 (31%) 2 (29%) and 3 (16%). 24% of the patients were Stage I, 19% Stage II, 17% Stage III and 28% Stage IV. Bulky disease was present in 19% of the patients. The extra-nodal localizations most frequently affected were: Waldeyer ring 22%, followed by Spleen, Liver and Bone. Marrow with the percentage in each been 11%. 70% CR was achieved and 12% PR. More than 50% of the patients have had more than an 8-year follow-up and the disease-free survival rate at 13 years is 32%. A multivariant analysis, according to histological degree, primary localization and stage, will be presented.