Invasive surgical instrument

Invasive surgical instrument having a proximal end and a distal end with an ultrasonic source (20; 30; 40) which generates a therapeutically effective ultrasonic radiation in the frequency range 30 kHz to 200 kHz, and a laser beam source (7), comprising a therapeutically effective laser radiation in the frequency range generated between 300 nm and 3 microns, at the proximal end and a leading from the proximal to the distal end, a waveguide (3; 48) forming glass fiber for the transmission of ultrasonic radiation and generated by the ultrasound source of the laser radiation generated by the laser beam source to the distal end of the instrument ,