Effect of intravenous iron sucrose in the treatment of elderly heart failure with preserved ejection fraction and iron deficiency

Objective To discuss the effect of intravenous iron sucrose in the treatment of elderly heart failure with preserved ejection fraction(HFpEF) and iron deficiency(ID). Methods From June 2016 to December 2016, 89 elderly patients with HFpEF and ID(age≧65 years old) in Anyang Prefecture Hospital were randomly divided into treatment group (n=45) and control group(n=44). The two groups were treated with routine drugs for heart failure.The treatment group was intravenously given iron sucrose injection once a week on the basis of conventional treatment.The SF, TS and Hb were tested in the two groups every month.The echocardiography Doppler, six minutes walk test(6MWT) and N-terminal probrain natriuretic peptide(NT-proBNP) before and after experiment were examined in two groups.The changes of left artial diameter(LAD), the mitral valve early flow velocitye/the late diastolic blood flow velocity ratio(E/A), left ventricular end diastolic(LVEDD), 6MWT, NT-proBNP were observed in the two groups before and after six months treatment. Results Before treatment, the levels of ST, TS, Hb, LAD, LVEDD, NT-proBNP, E/A, 6MWT in the two groups had no statistically significant differences(P>0.05). After treatment for 6 months, the levels of ST, TS and Hb in the treatment group were significantly higher than those in the control group[(244.23±1.69)μg/L vs.(30.70±7.11)μg/L, (26.17±1.15)% vs.(10.10±9.31)%, (132.08±3.15)g/L vs.(111.0±0.08)g/L](t=32.661, 9.881, 25.123, all P<0.05). The levels of LVEDD, LAD and NT-proBNP of the treatment group were significantly lower than those of the control group[(50.70±7.11)mm vs.(54.23±1.69)mm, (32.17±0.35)mm vs.(36.10±3.31)mm, (1077.17±9.35)ng/L vs.(1636.10±0.31)ng/L](t=8.123, 6.984, 11.484, all P<0.05). The levels of E/A, 6MWT of the treatment group were significantly higher than those of the control group[(1.18±0.15) vs.(0.97±0.33), (414.23±5.69)m vs (350.70±7.11)m](t=4.168, 12.123, all P<0.05). Conclusion Intravenous iron sucrose can improve cardiac function in the elderly patients with HFpEF and ID. Key words: Heart failure; Stroke volume; Iron compounds; Aged