The whole-genome landscape of medulloblastoma subtypes

Paul A. Northcott,Ivo Buchhalter,A. Sorana Morrissy,Volker Hovestadt,Joachim Weischenfeldt,Tobias Ehrenberger,Susanne Gröbner,Maia Segura-Wang,Thomas Zichner,Vasilisa A. Rudneva,Hans-Jörg Warnatz,Nikos Sidiropoulos,Aaron H. Phillips,Steven E. Schumacher,Kortine Kleinheinz,Sebastian M. Waszak,Serap Erkek,David T. W. Jones,Barbara C. Worst,Marcel Kool,Marc Zapatka,Natalie Jäger,Lukas Chavez,Barbara Hutter,Matthias Bieg,Nagarajan Paramasivam,Michael Heinold,Zuguang Gu,Naveed Ishaque,Christina Jäger-Schmidt,Charles D. Imbusch,Alke Jugold,Daniel Hübschmann,Thomas Risch,Vyacheslav Amstislavskiy,Francisco German Rodriguez Gonzalez,Ursula D. Weber,Stephan Wolf,Giles W. Robinson,Xin Zhou,Gang Wu,David Finkelstein,Yanling Liu,Florence M.G. Cavalli,Betty Luu,Vijay Ramaswamy,Xiaochong Wu,Jan Koster,Marina Ryzhova,Yoon-Jae Cho,Scott L. Pomeroy,Christel Herold-Mende,Martin U. Schuhmann,Martin Ebinger,Linda M. Liau,Jaume Mora,Roger E. McLendon,Nada Jabado,Toshihiro Kumabe,Eric Chuah,Yussanne Ma,Richard A. Moore,Andrew J. Mungall,Karen L. Mungall,Nina Thiessen,Kane Tse,Tina Wong,Steven J.M. Jones,Olaf Witt,Till Milde,Andreas von Deimling,David Capper,Andrey Korshunov,Marie-Laure Yaspo,Richard W. Kriwacki,Amar Gajjar,Jinghui Zhang,Rameen Beroukhim,Ernest Fraenkel,Jan O. Korbel,Benedikt Brors,Matthias Schlesner,Roland Eils,Marco A. Marra,Stefan M. Pfister,Michael D. Taylor,Peter Lichter

The whole-genome landscape of medulloblastoma subtypes

2017

Paul A. Northcott
Ivo Buchhalter
A. Sorana Morrissy
Volker Hovestadt
Joachim Weischenfeldt
Tobias Ehrenberger
Susanne Gröbner
Maia Segura-Wang
Thomas Zichner
Vasilisa A. Rudneva
Hans-Jörg Warnatz
Nikos Sidiropoulos
Aaron H. Phillips
Steven E. Schumacher
Kortine Kleinheinz
Sebastian M. Waszak
Serap Erkek
David T. W. Jones
Barbara C. Worst
Marcel Kool
Marc Zapatka
Natalie Jäger
Lukas Chavez
Barbara Hutter
Matthias Bieg
Nagarajan Paramasivam
Michael Heinold
Zuguang Gu
Naveed Ishaque
Christina Jäger-Schmidt
Charles D. Imbusch
Alke Jugold
Daniel Hübschmann
Thomas Risch
Vyacheslav Amstislavskiy
Francisco German Rodriguez Gonzalez
Ursula D. Weber
Stephan Wolf
Giles W. Robinson
Xin Zhou
Gang Wu
David Finkelstein
Yanling Liu
Florence M.G. Cavalli
Betty Luu
Vijay Ramaswamy
Xiaochong Wu
Jan Koster
Marina Ryzhova
Yoon-Jae Cho
Scott L. Pomeroy
Christel Herold-Mende
Martin U. Schuhmann
Martin Ebinger
Linda M. Liau
Jaume Mora
Roger E. McLendon
Nada Jabado
Toshihiro Kumabe
Eric Chuah
Yussanne Ma
Richard A. Moore
Andrew J. Mungall
Karen L. Mungall
Nina Thiessen
Kane Tse
Tina Wong
Steven J.M. Jones
Olaf Witt
Till Milde
Andreas von Deimling
David Capper
Andrey Korshunov
Marie-Laure Yaspo
Richard W. Kriwacki
Amar Gajjar
Jinghui Zhang
Rameen Beroukhim
Ernest Fraenkel
Jan O. Korbel
Benedikt Brors
Matthias Schlesner
Roland Eils
Marco A. Marra
Stefan M. Pfister
Michael D. Taylor
Peter Lichter

Genomic analysis of 491 medulloblastoma samples, including methylation profiling of 1,256 cases, effectively assigns candidate drivers to most tumours across all molecular subgroups.

Keywords:

Methylation
CNS cancer
Genetics
Genome
Medulloblastoma
Biology
Genomics
Whole genome sequencing
DNA methylation
Carcinogenesis
Mutation
DNA Mutational Analysis

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