Significantly Decreased and More Variable Expression of Major CYPs and UGTs in Liver Microsomes Prepared from HBV-Positive Human Hepatocellular Carcinoma and Matched Pericarcinomatous Tissues Determined Using an Isotope Label-free UPLC-MS/MS Method

Tongmeng Yan,Song Gao,Xiaojuan Peng,Jian Shi,Cong Xie,Qiang Li,Linlin Lu,Ying Wang,Fuyuan Zhou,Zhongqiu Liu,Ming Hu

Significantly Decreased and More Variable Expression of Major CYPs and UGTs in Liver Microsomes Prepared from HBV-Positive Human Hepatocellular Carcinoma and Matched Pericarcinomatous Tissues Determined Using an Isotope Label-free UPLC-MS/MS Method

2015

Tongmeng Yan
Song Gao
Xiaojuan Peng
Jian Shi
Cong Xie
Qiang Li
Linlin Lu
Ying Wang
Fuyuan Zhou
Zhongqiu Liu
Ming Hu

Purpose To determine the liver expression of cytochrome P450 (CYPs) and uridine 5’-diphosphate-glucuronosyltransferases (UGTs), the major phase I and II metabolism enzymes responsible for clearance and detoxification of drugs, xenobiotic and endogenous substances.

Keywords:

Uridine
Microsome
Enzyme
Metabolism
Cytochrome P450
Hepatocellular carcinoma
Endogeny
Pharmacology
Xenobiotic
Biochemistry
Chromatography
Chemistry
Variable Expression

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