Genetic models of Candida infection and host resistance factors

Infections caused by the yeast Candida albicans can occur on the skin, on mucous surfaces, or in disseminated form throughout the body and corresponding models have been developed in vivo. Patterns of infection differ in inbred mice, and the variability has been shown to be genetically regulated. The availability of gene-knockout mice, has also contributed significantly to an understanding of the cellular and molecular basis of the host response.