The Association among Genotypes of Apoe Gene with Lipid Profile and Internal Carotid Artery Intimal-Media Layer Thickness in Post Ischemic Stroke Patients

2 Abstract: Genetic factor has been thought to be a key factor in susceptibility to atherosclerosis, which can progress to ischemic stroke. Apolipoprotein E gene (ApoE) which involved in lipid metabolism, has six genotypes ie 2/ 2, 3/ 3, 4/ 4, 4/ 3, 4/ 2, 3/ 2 and often found in the incidence of atherosclerosis. To evaluate the association among genotypes of ApoE gene with lipid profile and intima-media thickness (IMT) of internal carotid artery, especially atherosclerosis in post-ischemic stroke patients in Dr. Kariadi Hospital Semarang, Indonesia. This was cross sectional study, carried out from January 2011 - March 2011. Sample was taken consecutively and by filling out the questionnaire, blood laboratory tests and examining the genotypes. The internal carotid artery IMT was examined by using carotid duplex ultrasound. The data were analyzed by using appropriate statistical methods. Results revealed that there were significant differences in HDL cholesterol levels and internal carotid artery IMT in 2/ 3 genotype compared with other genotypes (respectively, p = 0.005 and p = 0.030). There was no association between dyslipidemia and lipid profile abnormalities with ApoE gene genotypes. There was no significant association between ApoE gene genotypes with internal carotid artery atherosclerosis. There was significant differences in LDL cholesterol levels between subjects with and without atherosclerosis (p = 0.044). There were no significant association between various risk factors with IMT, especially internal carotid artery atherosclerosis. There were associations between ApoE gene 2/ 3 with high levels of HDL cholesterol and lower internal carotid artery IMT in post-ischemic stroke patients. There were no association between ApoE gene genotypes with internal carotid artery atherosclerosis. There was association between LDL cholesterol levels with internal carotid artery atherosclerosis.