Mediators of the relationship between social activities and cognitive function among older Irish adults: results from the Irish longitudinal study on ageing

ABSTRACTObjective: Evidence points to an association between social and leisure activity (SLA) engagement and cognitive outcomes, but the mechanisms underlying this link remain unknown. We aimed to investigate three potential mechanisms: Vascular function, Perceived Stress, and Cognitive Reserve.Methods: With data from 8163 adults aged over 50 in the Irish Longitudinal Study of Ageing, we used a structural equation model to evaluate Vascular Function and Perceived Stress as potential mediators, and Cognitive Reserve as a potential antecedent in the relationship between SLA at baseline (2009), and cognitive outcomes collected at a two-year follow-up point (2011).Results: Cognitive Reserve was strongly associated both with cognitive outcomes (β = 0.306; p < 0.001) and with SLA (β = 0.694; p < 0.001). Perceived stress (β = 0.018) acted as a significant mediator in the relationships between SLA and cognitive outcomes (p < 0.001), although Vascular Function did not (β = 0.000).Conclusion: These results indicat...