Hsp90 inhibition has opposing effects on wild-type and mutant p53 and induces p21 expression and cytotoxicity irrespective of p53/ATM status in chronic lymphocytic leukaemia cells.

Ke Lin,Nichola Rockliffe,Gillian G. Johnson,Paul D. Sherrington,Andrew R. Pettitt

Hsp90 inhibition has opposing effects on wild-type and mutant p53 and induces p21 expression and cytotoxicity irrespective of p53/ATM status in chronic lymphocytic leukaemia cells.

2008

Ke Lin
Nichola Rockliffe
Gillian G. Johnson
Paul D. Sherrington
Andrew R. Pettitt

Hsp90 inhibition has opposing effects on wild-type and mutant p53 and induces p21 expression and cytotoxicity irrespective of p53/ATM status in chronic lymphocytic leukaemia cells

Keywords:

Hsp90
Gene expression
Cancer research
Chronic lymphocytic leukemia
Wild type
Mutant
Carcinogenesis
Cytotoxicity
Molecular biology
Tumor suppressor gene
Biology

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