The prognostic impact of serum albumin in double hit/double expressing aggressive B cell lymphomas: A pilot study evaluating SAAB scoring system.

e19044Background: Double hit lymphomas (DHL) [rearrangements of MYC and BCL2/BCL6, and double expressing lymphomas (DEL) [expression of MYC and BCL6/BCL2 by immunohistochemistry] represent a subset of diffuse large B-cell lymphoma (DLBCL) with poor overall survival (OS). Several prognostic scores have been tested to clinically stratify these patients with the double hit score (DHS) being the most recently developed model (Petrich 2014). We explored the use of serum albumin (SA) as prognostic factor in DHL as previously shown in DLBCL (Dalia 2013). Methods: We included 100 patients from Moffitt Cancer Center database from January 2008 to December 2015 with DHL and performed a retrospective chart review. Recorded clinical data included SA, hemoglobin, age, International Prognostic Index (IPI), DHS, and lymphopenia. Pairwise Cox Comparison was used to develop a weighted scoring system. Kaplan-Meier method with Cox proportional hazard model was used to determine OS. Results: The median age was 63 (18-87), sta...