Neoformação óssea ao redor de implantes de titânio com superfície tratada inseridos em ratos diabéticos

Objective: This study aimed to compare the bone formation around titanium implants with machined and acid-etched surfaces, inserted in induceddiabetic rats and in non-diabetic rats, in an attempt to investigate whether there are differences in bone formation between this metaboliccondition and the use of different implant surfaces. Methods: Custom fabricated commercially pure solid cylinder titanium implants, machined and acid-etched surface were inserted in the femora of streptozotocin-induced diabetic rats (n=10) and non-diabetic rats (n=10). Morphometrical bone-implant contact percentage and bone area within the limits of the implant threads (BD) were performed at 21 days of healing. Results: Peri-implant tissue in machined implant showed intense new bone formation within all threads of the implants of the non-diabetic group (BIC= 82.8 ± 9.23 e BD = 38.7 ± 4.27) while diabetic group (BIC = 35.3 ± 9.4 and BD = 20.0 ± 3.8) exhibited small and immature bone formationwithin threads of the implants with thickness fibrous connective tissue interposition between bone-implant interface. In the acid-etchedsurface implants in both, diabetic and non-diabetic groups, the peri-implant tissue showed intense new bone formation within all threads ofthe implants with BIC = 74.4 ± 14.7 e BD = 35.4 ± 3.48 in non-diabetic group and BIC = 63.1 ± 12.9 e BD = 29.6 ± 4.9 in diabetic group.Conclusion: In machined surface implants the diabetes interfere negatively in osseointegration while acid-etched surface promoted major BIC and BD index, indicating its selective use in diabetic patients. Objetivo: Comparar a formacao ossea ao redor de implantes de superficie lisa e tratada, instalados em ratos diabetico-induzidos e nao-diabeticos,investigando se ha diferencas na formacao ossea entre os dois quadros metabolicos, melhora no padrao de osteogenese entre as diferentessuperficies e, sua relacao com o diabetes. Metodos: Foram instalados implantes de titânio de superficies lisa e tratada, no femur de ratos diabetico-induzidos com estreptozotocina (n=10) e nao diabeticos (n=10).A Analise morfometrica da porcentagem de contato osso-implante (COI) foi realizada 21 dias apos a cirurgia. Resultados: A neoformacao ossea foi intensa ao redor dos implantes de superficie lisa nos ratos nao-diabeticos (COI = 82.8 ± 9.23), enquanto que o grupo diabetico exibiu pequena e imatura formacao ossea (COI=35.3 ± 9.4), com interposicao de tecido conjuntivo na interface osso-implante. Ao redor dos implantes com superficie tratada, ocorreu intensa neoformacao ossea, tanto nos animais diabeticos (COI = 63.1 ± 12.9) como nos nao-diabeticos, (COI = 74.4 ± 14.7). Conclusao: Nos implantes de superficie lisa, o diabetes interfere negativamente na osseointegracao, enquanto que as superficies tratadas com acido promoveram maior contato osso-implante, indicando seu uso seletivo em pacientes diabeticos.