Characterisation of Factor VIII Receptors

The Factor VIII complex consists of at least two distinct gene products — a relatively small X-chromosomal gene product known as Factor VIII:C, or Factor VIII coagulant, whose absence is the hallmark of hemophilia A, and an autosomal gene product, representing the bulk of the complex, disturbances in whose synthesis characterize the bleeding disorders collectively known as von Willebrand1 s disease, from whence it derives its name, the von Willebrand factor (vWf) (1).