CombinedChemisorption and Complexation Generate siRNA Nanocarriers with BiophysicsOptimized for Efficient Gene Knockdown and Air–Blood BarrierCrossing

Alexander Taschauer,Wolfram Polzer,Stefan Pöschl,Slavica Metz,Nathalie Tepe,Simon Decker,Norbert Cyran,Julia Scholda,Julia Maier,Hermann Bloß,Martina Anton,Thilo Hofmann,Manfred Ogris,Haider Sami

CombinedChemisorption and Complexation Generate siRNA Nanocarriers with BiophysicsOptimized for Efficient Gene Knockdown and Air–Blood BarrierCrossing

2020

Alexander Taschauer
Wolfram Polzer
Stefan Pöschl
Slavica Metz
Nathalie Tepe
Simon Decker
Norbert Cyran
Julia Scholda
Julia Maier
Hermann Bloß
Martina Anton
Thilo Hofmann
Manfred Ogris
Haider Sami

Current nucleic acid (NA) nanotherapeutic approaches face challenges because of shortcomings such as limited control on loading efficiency, complex formulation procedure involving purification step...

Keywords:

Biodistribution
Materials science
Nucleic acid
Nanocarriers
luciferase reporter gene
Biophysics
Gene knockdown
Colloidal gold
sirna knockdown
Organic chemistry

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