Determination of Caffeine and its Metabolites in Saliva and Urine as a Measure of CYP1A2 Metabolic Activity

Byla vyvinuta nova citliva a robustni RP-HPLC metoda pro stanoveni kofeinu, 1,7 dimethylxanthinu, 1,7-dimethylmocove kyseliny, 5-acetylamino-6-formylamino-3-methyluracilu, 5-acetylamino-6-amino-3-methyluracilu, 1-methylxanthinu a 1-methylumocove kyseliny ve slinach a moci. Metoda slouži ke stanoveni metabolicke aktivity CYP1A2.