Abstract 15645: Plasma Trans-fatty Acids and Lipid and Lipoprotein Concentrations Among U.S. Adults: Findings From NHANES 1999-2000 and 2009-2010

Introduction: High intake of trans-fatty acids (TFAs), especially industrially-produced TFA, can lead to unfavorable lipid and lipoprotein concentrations and increased risk for cardiovascular disease. It is unknown how this relationship might change after significant reductions in TFA intake occurs in population. Our objective was to examine the association between plasma TFA levels and lipid and lipoprotein concentrations before and after the U.S. Food and Drug Administration enacted food labeling regulations for TFAs in 2006. Hypothesis: The association between plasma TFA levels and lipid and lipoprotein concentrations will become undetectable after significant reductions in TFA intake in a population. Methods: Data were selected from National Health and Nutrition Examination Surveys of 1999-2000 and 2009-2010. Findings on 1477 and 2348 adults, respectively, aged ≥20 years, were compared. Multivariable linear regressions were used to examine the associations between plasma TFA levels and lipid and lipop...