Association of TRIB3 gene +251A/G polymorphism with carotid atherosderosis in hypertensive patients

Objective To investigate the effect of TRIB3 gene polymorphism on carotid atherosclerosis in hypertensive patients. Methods A total of 400 subjects were recruited in.the study including control group ( n =200) and hypertension group ( n =200). These 400 subjects were genotyped using polymerase chain reaction-restrictive fragment length polymorphism ( PCR-RFIP). All of them underwent carotid ultrasonography.Results Compared to the controls,the hypertensive patients showed increased IMT ( t =39.223,P ＜ 0.01) ; The CG allele carriers had more thickened IMT than the AA allele carriers ( t =22.235,P ＜ 0.001) ; The Logistic regression analysis suggested that the G allele is the risk factors for carotid atherosclerosis ( OR =2.116, 95％ CI:1.045 ～4.721, P =0.031). Furthermore,waist circumference,systolic blood pressure and fasting blood glucose are risk factors for thickened IMT.Conclusion Those hypertensive patients carrying TRIB3 gene +251A/G polymorphism G allele were susceptible to carotid atherosclerosis =Hypertension;Carotid atherosclerosis ;TRIB3 ;Polymorphism Key words: Hypertension; Carotid atherosclerosis ; TRIB3 ; Polymorphism