Analogs of the water soluble camptothecin.

Compounds of formula (I) wherein X is OH, H, cyano, - CH2NH2 or formyl; R is H when X is cyano, - CH2NH2 or formyl, OR IS - CHO, or - CH2R when X is HO OH; R1 is - OH - R2; - S - R2 - N - R2 (R3) N + O - R2 - (R3) (R4); R2, R3 and R4 are identical or different and are selected from H, alkyl of 1 to 6 C, hydroxyalkyl 2 A 6 C, or dialkylamino, dialkylaminoalkyl, alkylaminoalkyl or aminoalkyl (where Alkyl groups have up to 6 C) O carbocyclic ring of 3 to 7 members which may be substituted; And when R1 is - N - R2 (R3) GROUP R2 and R3 may combine to form a ring ALSO REFERRED TO THE INVENTION TO SALES hydrates and SALOATOS pharmaceutically acceptable of these compounds, processes for their preparation Intermediates USED IN Preparation thereof PHARMACEUTICAL COMPOSITIONS AND USE IN THERAPY CONTAINING INHIBITORS AS GROWTH OF tUMOR CELLS.