Распространенность коморбидной патологии у больных острым инфарктом миокарда и ее влияние на интенсивность системной воспалительной реакции

499 patients with acute myocardial infarction (AMI) were examinated. In general comorbidity amount was 48%. It is shown that the majority-94% had AMI which was developed on arterial hypertension (AH). Main comorbidities were diabetes mellitus type 2 – 22%, chronic obstructive pulmonary disease – 13%, anemia – 18%, peptic ulcer – 6%. Under these circumstances AMI run became more severe: the number of complications such as pulmonary edema and cardiogenny shock increased in 1,5 times, and in-hospital mortality also rose in comparison with only AMI and AH diseased, but the differences do not represent statistical significance. The systemic inflammatory reaction (SIR) intensity to myocardial ischemia was evaluated by integral leucocytar index of peripheral blood taken within the first hour of hospitalization. Initial hypo-, norm – and hyperreactive types of SIR in groups of patients with comorbid pathology and without it were defined in accordance with the established threshold levels of indexes. It is determined that the share of persons with different severity SIR in the group does not have significant differences. Hyperreactivity type of systemic inflammation in the acute period AMI is prevailing – 43-49% regardless of the presence or absence of comorbidity.