Safety and efficacy of chymopapain (Discase) in the treatment of sciatica due to a herniated nucleus pulposus. Results of a randomized, double-blind study.

A prospective, multiInstitutional, double-blind trial comparing the effect of chymopapain (Disease) vs. placebo (cysteine-edetate-iothalamate: CEI) for lumbar Inter-vertebral disc rupture with sciatica was carried out on 173 patients, the largest such study reported to date. Patients were matched wi