Clinical study of trans-bronchoscope local perfusion of amphotericin B in the treatment of pulmonary fungal infection

Objective To evaluate the efficacy of trans-bronchoscope local perfusion of amphotericin B on the treatment of pulmonary fungal infection.Methods Twenty-two patients with pulmonary fungal infection were randomly divided into two groups:Patients in treatment group (11 cases) were given systemic application of voriconazole (4 mg/kg,once every 12 hours) combined with bronchoscope local perfusion amphotericin B 25 mg and 10 ml physiological saline; Patients in control group(11 cases) were given systemic application of voriconazole (4 mg/kg,once every 12 hours).Results The effective rate of treatment group (81.8％) was higher than that of control group (54.5％),the difference was statistically significant (P ＜ 0.05),and there was no significant adverse reactions occurred.Conclusions Bronchoscope alveolar perfusion of amphotericin B in the treatment of pulmonary fungal infection is safe and effective,economic and has short course. Key words: Bronchoscope ;  Amphotericin B ;  Fungal infection