Comparison Between High-Intensity and High-Volume Resistance Training on the Acute Myokine Response in Resistance Trained Men

Secreted protein acidic and rich in cysteine (SPARC) and musclin are myokines implicated in glucose uptake signaling. SPARC has been shown to increase expression of GLUT4 on myocytes, while musclin has been shown to inhibit insulin signaling, suggesting a possible increased reliance on fat metabolism during exercise. SPARC and musclin concentrations have been shown to increase in response to acute exercise. However, the effect of different resistance training paradigms on changes in the plasma concentrations of these myokines remain unknown. The purpose of this study was to examine the acute response of these myokines following two commonly utilized resistance training paradigms. Twenty resistance trained men volunteered to participate in this study. Following a two-week preparatory period, participants were randomly assigned to either a high-intensity (HI; n=10, 22.6±2.3 y; 87.0±15.1 kg; 1.79±0.05m) or high-volume (HV; n=10, 24.5±2.6 y; 89.5±12.9 kg; 1.66±0.34m) group. Prior to the first training session...