Role of TRAIL pathway and NKG2D pathway in double negative T cell cell anti-tumor

Double negative T cell is a rare type of cells that regulates immune responses in a way that is unique. In the process of adoptive immunotherapy, it gradually becomes a hot spot, because of its obvious anti-tumor effect. However, the mechanism by which DNT cell kills tumor cell is not clear. Tumor necrosis factor-related apoptosis-inducing ligand(TRAIL) and natural-killer group 2, member D (NKG2D) pathway is a more important part of its killing mechanism, and NKG2D receptor can also regulate the production of soluble TRAIL, making the two channels to establish a certain link. In this paper, the effect of Double negative T cell and the mechanism of TRAIL and NKG2D pathway in DNT cell′s anticancer were described. Key words: Immunity; Pancreatic neoplasms; DNT cell; TRAIL; NKG2D