Loss-of-function of PTPR γ and ζ, observed in sporadic schizophrenia, causes brain region-specific deregulation of monoamine levels and altered behavior in mice

Arnaud Cressant,Veronique Dubreuil,Jing Kong,Thorsten M. Kranz,Françoise Lazarini,Jean-Marie Launay,Jacques Callebert,Jan Sap,Dolores Malaspina,Sylvie Granon,Sheila Harroch

Loss-of-function of PTPR γ and ζ, observed in sporadic schizophrenia, causes brain region-specific deregulation of monoamine levels and altered behavior in mice

2017

Arnaud Cressant
Veronique Dubreuil
Jing Kong
Thorsten M. Kranz
Françoise Lazarini
Jean-Marie Launay
Jacques Callebert
Jan Sap
Dolores Malaspina
Sylvie Granon
Sheila Harroch

Rationale The receptor protein tyrosine phosphatase PTPRG has been genetically associated with psychiatric disorders and is a ligand for members of the contactin family, which are themselves linked to autism spectrum disorders.

Keywords:

Endocrinology
Internal medicine
Autism
Loss function
Psychology
Dopamine
Protein tyrosine phosphatase
Schizophrenia
Monoamine neurotransmitter
Receptor
Phosphatase

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