Sex inversion in domestic chicken ( Gallus gallus domesticus ) by letrozole and tamoxifen

In multicellular organisms, determination of sex identity is a complex, multistage process. Sex hormones are synthesized in gonads and fulfill the role of inductors in this process. The effect of androgen is currently well studied. However, the participation of estrogen in the formation of female gonads and female sex on the whole is not much known. Here, we present the results of experimental sex inversion by inhibition of aromatase (an enzyme involved in estrogen synthesis) and tamoxifen (a modulator of estrogen receptors) in chick embryos. It was shown that masculinization depended on the dose of the substance and quantity of injections. Inhibition of aromatase did not block the meiotic prophase in oogoniums. It has been suggested that retinoic acid and estrogens have different mechanisms of effect on oogenesis. Proteins and nucleoproteins interacting with estrogen receptor 1 and their gene localization in human and chicken genomes have been shown for the first time.