Production of 3,5-difluoroaniline

PURPOSE: To synthesize 3,5-difluoroaniline in high yield in production stages which can be technically easily controlled from a source material which is industrially easily available. CONSTITUTION: The 3,5-difluoroaniline of the purpose is produced in the below- mentioned processes. First, 2,4,5-trichloronitrobenzene is reacted with an alkali metal fluoride at about 100 to 250°C in the presence or absence of a polar aprotic solvent. The crude soln. after the precipitated salt is removed by filtration is fractionated by distillation to obtain 5-chloro-2,4-difluoronitrobenzene. The obtd. product is subjected to denitration and chlorination by using an anhydrous chlorine gas in the absence of Lewis acid and or another chlorination catalyst at about 80 to 250°C. The obtd. compd. is nitrated at about 15 to 80°C with a mixture acid in oleum gas. Further, the compd. is reduced with hydrogen in the presence of palladium and a base at about 40 to 250°C. COPYRIGHT: (C)1994,JPO