The Research Status of Class II Histone Deace-tylases Physiological Function

Histone deace-tylases (HDACs) are proteases, The main function of HDACs are to modify the structure of chromosomes and regulate gene expression in organisms. HDACs can catalyze the deacetylation of histones, regulate histone acetylation process and deacetylation process in the nucleus, and maintain its dynamic balance state, which is closely related to the occurrence of cell apoptosis, oxidative stress and with it inflammatory response, metabolic disorders, senescence, tumor and other processes in living things. There are many members of the HDACs family, as many as 18 of which have been discovered so far, was divided into classesI, classesIIa, classesIIb, classesIII and classesIV, The structure, function, subcellular localization and expression patterns of each enzyme are not the same. In recent years, the physiological function of classII HDACs is more widespread attention by researchers, In this paper, we will review the physiological function of classII HDACs in the regulation of bone formation, skeletal muscle regulation, cardiovascular growth and formation, endothelial cells, cytoskeletal dynamics and so on, It also gives a brief description of possible research directions of HDACs, so that it can be widely used in clinical treatment and play a positive therapeutic role.