Prognosis of large vessel involvement in large vessel vasculitis

Abstract Objectives To assess prognosis factors and outcome of large vessel involvement (LVI) in large vessels vasculitis (LVV) patients. Methods Retrospective multicenter study of characteristics and outcomes of 417 patients with LVI including 299 Takayasu arteritis (TAK) and 118 Giant cell arteritis (GCA-LVI) were analyzed. Logistic regression analysis assessed prognosis factors in LVV patients. Outcome of LVI among TAK and GCA-LVI patients (ischemic complications, aneurysms complications, relapses and revascularization) were assessed. Results In multivariable analysis, stroke/transient ischemic attack [HR: 3.63 (1.46–9.04), p = 0.006] was independently associated with vascular complications in LVV. The 10-years aneurysm free survival was significantly lower [67% (48–93) vs 89% (84–95), p = 0.02] in GCA-LVI compare to TAK patients. The 5-years relapse free survival was significantly lower [47% (37–60) vs 69% (63–75), p  Conclusion This large nationwide cohort of LVI provided prognosis factors of vascular complications in LVV patients. TAK and GCA-LVI have different long-term outcome in term of aneurysm development, relapse and revascularization.