Abstract 4515: Low serum levels of a novel anti-inflammatory fatty acid as a new risk factor for colorectal cancer

Low serum levels of novel, long-chain, hydroxylated and polyunsaturated fatty acids (GTAs) in colorectal cancer (CRC) patients has been previously reported. This study prospectively investigated the relationship between serum GTA levels and CRC incidence among subjects undergoing colonoscopy. Serum samples and pathology data were collected from 4923 representative subjects undergoing colonoscopy in a typical, non-screening, colonoscopy population and from 964 representative age and geographically-matched subjects from the general population. Serum GTA-446 levels were determined on all subjects using a sensitive tandem mass spectrometric method. A low serum GTA-446 level was defined as a GTA-446 concentration below the tenth percentile of 40-49 year-olds in the general population sampling. Eighty-six percent of newly diagnosed CRC subjects (87% for stage 0-II and 85% for stage III-IV) were observed to have low serum GTA-446 levels, with a PPV of 15% and NPV of 99.7%. CRC incidence was observed to increase significantly with age in all subjects (p Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4515. doi:1538-7445.AM2012-4515