Synthesis and anticandidal activities of optimized analogs of antibiotic Sch 37137.

Peptide analogues of Sch 37137 the antifungal antibiotic have been synthesized and evaluated in vitro against Candida sp. Di- and tripeptides containing methionine, leucine, norvaline, lysine, glutamic acid and N3-(trans-epoxysuccmamoyl)-L-2, 3-diaminopropanoic acid, (EADP) were obtained. Peptides containing (d)-, and (L)-trans-epoxysuccinamic acid were also prepared. All of the analogues examined displayed in general higher anticandidal activity than a mixture of diastereomers of Sch 37137.