Association of serum α2-HS-Glycoprotein concentration with glucolipid metabolism in patients with gestational diabetes.

Objective To investigate the relationship among serum AHSG levels and glucolipid metabolism.Method Enzyme-linked immunosorbent assay was used to measure the fasting serum AHSG levels of 30 cases of women with GDM,30 cases of normal pregnant women in late pregnancy.Fasting total cholesterol (TC),triglyceride (TG),very low-density lipoprotein cholesterol (VLDL-C),and fasting plasma glucose (FPG),glycosylated hemoglobin A1c (HbA1c) were also measured at the same time.Results (1) Significantly elevated serum AHSG concentration was found in the women with GDM as compared with the normal pregnant women ( P0.01 ).(2) The concentration of serum TC,TG,FPG,HbA1c and VLDL-C in GDM group were significantly higher than those of normal pregnancy group(P0.05 or P0.01).(3) Univariate linear correlation and regression analysis showed that the serum AHSG level is positively correlated with TC,TG,VLDL-C,FPG,HbA1c,weight gain during pregnancy and BMI in late pregnancy in GDM group,but no correlation between AHSG and progestational BMI was found.In normal group there are also significantly positive correlations between AHSG and FPG,HbA1c,weight gain during pregnancy was also found,but less significant than those in the GDM group;there is no correlations between AHSG and TC,TG,VLDL-C,progestational BMI,BMI in late pregnancy.Conclusion Fasting serum AHSG levels in pregnant women with GDM is significantly higher than in normal pregnant women.The increased AHSG may be involved in the formation of glycolipid metabolic disorders in pregnant women with GDM.