Simplified Symptoms-Based Score for the Assessment of Ischemic Stroke Severity (P07.003)

Objective: We assessed the reliability of the 6S score to predict stroke severity and outcome. Background We designed a symptoms-based scale for assessing stroke severity and outcome, the 6S score. Design/Methods: We analyzed a consecutive cohort of ischemic stroke patients admitted to our hospital between 2007 and 2010. The cohort was further subdivided into 2 groups of 120 (group A) and 90 (group B) patients. Group A was used for determining the likelihood ratios (LRs) of 6 components/symptoms for 3 outcome measures: (1) neurological worsening during hospitalization (NWH) defined as a difference ≥4 points between the National Institutes of Health Stroke Scale (NIHSS) on admission and that on discharge, (2) in-hospital mortality (IHM), and (3) unfavorable outcome during hospitalization (UOH) defined as either NWH or IHM. A value was assigned for each component by averaging its LRs for NWH, IHM, and UOH. Group B was used for assessing the area under the curve (AUC) of the 6S Score for each of the 3 outcome measures. We compared the AUC of the 6S Score with that of the NIHSS. Results: The 6 selected symptoms, (assigned values in parentheses) were: impaired level of consciousness (4 points), motor deficit (2 points), sensory deficit (2 points), aphasia (2 points), hemianopia (2 points), and cranial nerve involvement (3 points). The AUC of the 6S Score for NWH, IHM, and UOH in Group A was 0.74, 0.73 and 0.76, respectively; similar to that of the NIHSS (0.79, 0.91, and 0.80, respectively). The AUC in Group B was 0.83, 0.86, and 0.81 for the 6S Score and 0.92, 0.82, and 0.84 for the NIHSS. Conclusions: The 6S Score appears to be reliable measure acute IS severity and outcome. Further studies are needed to assess its reliability. Supported by: INECO Foundation. Disclosure: Dr. Racosta has nothing to disclose. Dr. Sposato has nothing to disclose. Dr. Sposato has nothing to disclose. Dr. Sposato has nothing to disclose. Dr. Sposato has nothing to disclose. Dr. Sposato has nothing to disclose. Dr. Sposato has nothing to disclose. Dr. Sposato has nothing to disclose.