Infrasound induces coronary perivascular fibrosis in rats

Abstract Background Chronic exposure to industrial noise is known to affect biological systems, namely, by inducing fibrosis in the absence of inflammatory cells. In rat hearts exposed to this environmental hazard, we have previously found myocardial and perivascular fibrosis. The acoustic spectrum of industrial environments is particularly rich in high-intensity infrasound ( Methods Adult Wistar rats were divided into three groups: group A (GA)—IFS ( image J software. Mann–Whitney and Kruskal–Wallis tests were used to compare the groups for lumen-to-vessel wall (L/W) and vessel wall-to-perivascular tissue (W/P) ratios. Results IFS-exposed rats exhibited a prominent perivascular tissue. The median L/W and median W/P ratios were 0.54 and 0.48, 0.66 and 0.49, and 0.71 and 0.68, respectively, in GA, GB, and GC. The W/P ratio was significantly higher in GC compared with IFS-exposed animals ( P =.001). The difference was significant between GC and GB ( P =.008) but not between GC and GA. Conclusion IFS induces coronary perivascular fibrosis that differs under treatment with corticosteroid.