Solvent Selection for the Separation of Lignin-Derived Monomers Using the Conductor-like Screening Model for Real Solvents
2020
The separation of desired monomers
from a liquid-phase mixture
of lignin depolymerization products is necessary to facilitate their
upscaling and upgrading for industrial applications. One effective
method to separate multiple liquid-phase products is countercurrent
chromatography (CCC), which is a common liquid chromatography technique
that separates target solutes based on differences in their partitioning
in a biphasic solvent system. Effective CCC separation requires the
selection of solvent compositions to tune solute partition coefficients.
To alleviate the experimental burden of selecting optimal solvent
systems, we apply the conductor-like screening model for real solvents
(COSMO-RS) method to compute partition coefficients of representative
lignin monomers from four currently used depolymerization strategies
in standard solvent systems. We further design new ternary and quaternary
solvent systems that are predicted to further improve separation efficacy.
On the basis of these predicted partition coefficients and empirical
solvent selection criteria for CCC measurements, we suggest a range
of solvent systems that would be suitable for the effective separation
of aromatic lignin-derived products via CCC or similar liquid–liquid
extraction methods.
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