Preparation of 2-Azabicyclo[2.1.1]hexane Hydrochloride
2016
A batchwise, multigram preparation of 2-azabicyclo-[2.1.1]hexane hydrochloride ( 1 ·HCl) was developed, delivering a total of 195 grams of material. The key synthetic step involves an intramolecular displacement of a primary alkyl chloride with a tert -butylsulfinamide to forge the [2.1.1]-bicyclic ring system.
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