Effect of lazaroid U-74389G on prolonged hepatic ischemia-reperfusion injury.

IN SPITE of progress in the field on liver transplantation, graft dysfunction due to ischemia-reperfusion injury frequently occurs after revascularization. Research efforts are crucial to determine the mechanism of reperfusion injury and to reduce its incidence. Lazaroids are a group of new synthetic 21-aminosteroids that inhibit iron-dependent lipid peroxidation without glucocorticoid and mineral ocorticoid actions. Lazaroids suppress cytokine production, adhesion molecule expression, and neutrophile activation and infiltration. We examined the effect of Lazaroid U-74389G on ischemia-reperfusion injury of the canine liver.