Investigations on the modification of postirradiation pancreatic lipase activity by some endo- or exogenic factors. Part II. The influence of some ions, biogenic amines and hormones.

: The subject of investigations was the influence of some endogenic substances: ions (K+ and Ca++), amines (serotonin, histamine and acetylcholine) and hormones (hydrocortisone and glucagon) on the lipase release from pancreatic granules (zymogen and lysosomes) of control and irradiated rats (800 R=24 hours). The decrease of enzyme release under the influence of hydrocortisone (both concentrations: 10(-6) and 10(-8) M), Ca++ ions, serotonin, histamine and acetylcholine after their administration in greater concentration (10(-6) M) was stated. Smaller concentrations of these substances evoked the transitory enhancement of enzyme activity. K+ ions and glucagon increased the lipase release (both concentrations). In the fraction of organelles from irradiated rats the action of K+ ions, glucagon and acetylcholine was diminished or abolished, while the inhibitory effectiveness (of greater concentrations) of Ca++ ions, serotonin, histamine and hydrocortisone was maintained.